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Georgia
Diclofenac buy in Mtskheta
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Diclofenac buy in Mtskheta
Buy Diclofenac
Diclofenac

Diclofenac

In stock
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Georgia, Mtskheta
+995 
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Description

Composition

Prolongirebuli of 1 coated tablet contains: Active substance: Diclofenac Sodium 100.0 mg Excipients: sucrose, tsetilis alcohol, anhydrous colloidal silicon dioxide, talc, Povidone K 25, magnesium stearate, hipromeloza, Titanium Dioxide, Polysorbate 80, 6000 makrogoli, paint Cochenillerotlack, Braunlack, FDC YellowN06 Al.lak.

Description

Prolongirebuli action, coated tablets 100 mg - round ორმხრივამოზნექილი tablets, coated varsiperi, ganatekh on white - almost white in color.

Pharmacotherapeutic group: anti-inflammatory arasteroioduli opportunity.
Atk code: M01AB05.

Pharmacological action
Diclofenac has an anti-inflammatory, analgesic, and antiagregantuli febrifugal action. Arasherchevitad suppresses tsiklooksigenazas 1 - and tsiklooksigenaza 2 -, reduces the number of inflammatory prostaglandins in the district. Anti-inflammatory and analgesic effects of diclofenac rheumatic diseases causing pain, tightness in the morning, the funds shesiebis reduction, which improves the current joint functional. Trauma, postoperative period, diclofenac reduces pain, and inflammatory edema.

Pharmacokinetics
Absorption - fast and complete, the food reduces the absorption bandwidth of 1-4 hours and reduces the maximum concentration (Cmax) 40% - respectively. 50 mg - The after oral administration Cmax-1.4 micrograms. ML is achieved in 2-3 hours. Introduced into the plasma concentration of linear dependence on the number of doses.
Following oral administration of 100 mg tablets, Cmax-0.5 mcg / mL miighetseva 4 hours. Diclofenac parmokokinetikis multiple input change does not occur in the background, does not accumulate.
Biomisatsvdomloba - 50%. Binding with connections - 99% - more than (most of which is related to albumin). Sinoviur fluid reaches of the maximum concentration in the liquid sinoviur 2-4 hours later than in plasma. Sinoviuri fluid from the half-life of 3-6 hours (sinoviur fluid active substance kontsentrtsia preapratis sheqvani 4-6 hours is higher than that in plasma and remained higher even 12 hours ganmvavloba is. Sinoviur fluid interaction preaparatis concentration and its clinical efficacy and some are not.
Metabolism in the liver metabolism of the active ingredient of 50% subject to "first pass". Hidrpksilirebis and koniugirebisas glukuronis acid metabolism occurs with multiple or single. Click on drug metabolism system P450 CYP2C9 enzyme.
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